Computational Approaches to Elucidating Transient Protein-Protein Interactions, Predicting Receptor-Ligand Pairings

Protein-protein interactions (PPI) are one of the most important biological events which occur in the cell. As PPIs regulate almost all biological processes in the cell, aberrations in PPI may cause severe health problems. One specific area of PPI is receptor-ligand interactions. These interactions are transient yet account for a large part of cell-to-cell communication. As PPI is an important area of research, many groups have proposed methods to make computational predictions of PPI.